Study of corrosion, biological and mechanical properties of biodegradable Zinc-Iron alloys with medical applications

Authors: Radka Gorejová 1    Zuzana Orságová Králová 1    Renáta Oriňaková 1    Andrej Oriňak 1    Miriam Kupková 2    Monika Hrubovčáková 2    Tibor Sopčák 2   
1 Univerzita Pavla Jozefa Šafárika, Prírodovedecká fakulta, Katedra fyzikálnej chémie, Košice, Slovenská republika    2 Ústav materiálových vied SAV, Košice, Slovenská republika   
Year: 2020
Section: Utilization of instrumental methods in the analysis of biologically important substances
Abstract No.: 1928
ISBN: 978-80-972360-6-9

Biodegradable metals used in orthopedics have gained a lot of attention in recent years mainly due to their good mechanical properties and biocompatibility [1]. Among them, zinc stands out with its excellent corrosion behavior in a physiological environment. However, the mechanical properties of pure zinc are unsatisfactory. This deficiency can be solved by alloying with different metals [2]. This work is devoted to the preparation and complex characterization of Zn-Fe binary alloys prepared from the elemental powders. Samples were sintered at 350 °C and their corrosion, mechanical and biological properties were tested. The microstructure and composition of the alloys were studied by SEM, EDX, and XRD methods. Corrosion properties were evaluated by electrochemical polarization tests in simulated body fluids at 37 °C and pH = 7,4. Besides that, the hemocompatibility of the samples was studied using healthy sheep blood. It was found that iron addition (1,2,5 or 10 wt.% respectively) did not enhance the mechanical properties. Corrosion rates of the alloyed samples were greater than that of pure zinc which was attributed to the micro-galvanic effect induced by the presence of the intermetallic Zn11Fe phase. Platelet adhesion tests of pure zinc and Zn-Fe alloys showed good anti-platelet properties. Overall, Zn-Fe alloys should serve as potential biodegradable scaffolds after their further in vivo biocompatibility tests.

This work was supported by the Slovak Research and Development Agency (APVV-16-0029), Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic (VEGA 1/0074/17) and Internal Research Grant System of Faculty of Science of Pavol Jozef Šafárik University in Košice (VVGS-PF-2019-1049).
[1] ZHENG, Y. F.; GU, X. N.; WITTE, F. Biodegradable metals. Materials Science and Engineering: R: Reports, 2014, 77: 1-34
[2] KATARIVAS LEVY, Galit; GOLDMAN, Jeremy; AGHION, Eli. The prospects of zinc as a structural material for biodegradable implants—a review paper. Metals, 2017, 7.10: 402.